PHARMACOLOGICAL AND TOXICOLOGICAL PROPERTIES OF ANTICOAGULANTOINTMENT
DOI:
https://doi.org/10.17605/OSF.IO/4Q2DMKeywords:
Safinol, salicylic acid, ε -amino-enanthic acid, ointment.Abstract
Treatment of thrombosis and embolism is currently one of the urgent problems of medicine. It is known that the body has universal resistance to a sudden increase in blood clotting, and only a sharp violation of the neuro-humoral regulation of hemostasis leads to vascular wall damage and the formation of blood clots.This paper presents the results of research on the development of its dosage form - safinol ointment and also pharmacological and toxicological properties
Downloads
References
Hirsh J., Anand S.S., Halperin J.L., Fuster V. // Mechanism of Action and Pharmacology of Unfractionated Heparin // Arteriosclerosis, Thrombosis, and Vascular Biology. — 2001. — V. 21. — P. 1094-1096.
Hirsh J., O’Donnell M., Eikelboom J.W. Beyond Unfractionated Heparin and Warfarin: Current and Future Advances // Circulation. — 2007. — V. 216. — P. 552-560.
Reich L.M., Folsom A.R., Key N.S. et al. Prospective study of subclinical atherosclerosis as a risk factor for venous thromboembolism // Journal of Thrombosis and Haemostasis. — 2006. — V. 4, № 9. — P. 1909-1913.
Wille-Jorgensen P., Jorgensen L.N., Crawford M. Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome. A systematic review and meta-analysis // Thrombosis &Haemostasis. — 2005. — V. 93. — P. 236.
Eriksson B.I., Borris L.C., Dahl O.E. et al. A Once-Daily, Oral, Direct Factor Xa Inhibitor, Rivaroxaban (BAY 59-7939), for Thromboprophylaxis After Total Hip Replacement // Circulation. — 2006. — V. 114. — P. 2374-2381.
Eriksson B.I., Borris L.C., Friedman R.J. et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty // New England Journal of Medicine. — 2008. — V. 358. — P. 2765-2775.
Escher R. Extensive venous thrombosis following administration of high-dose glucocorticosteroids and tranexamic acid in relapsed Evans syndrome // Blood Coagulation & Fibrinolysis. — 2008. — Vol. 19. — Issue 7. — Р. 741-742.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.















